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KMID : 1145520150010010023
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Journal of Radiopharmaceuticals and Molecular Probes
2015 Volume.1 No. 1 p.23 ~ p.30
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The production and application of therapeutic 67Cu radioisotope in nuclear medicine
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Kim Gye-Hong
Lee Kyo-Chul
Park Ji-Ae
An Gwang-Il
Lim Sang-Moo
Kim Jung-Young
Kim Byung-Il
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Abstract
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Radioisotopes emitting low-range highly ionizing radiation such as β-particles are of increasing significance in internal radiotherapy. Among the β-particle emitting radioisotopes, 67Cu is an attractive radioisotope for various nuclear medicine applications due to its medium energy β-particle, gamma emissions, and 61.83-hour half-life, which can also be used with 64Cu for PET imaging. The production and application of the β-emitting radioisotope 67Cu for therapeutic radiopharmaceutical are outlined, and different production routes are discussed. A survey of copper chelators used for antibody labeling is provided. It has been produced via proton, alpha, neutron, and gamma irradiations followed by solvent extraction, ion exchange, electrodeposition. Clinical studies using 67Cu-labelled antibodies in lymphoma, colon carcinoma and bladder cancer patients are reviewed. Widespread use of this isotope for clinical studies and preliminary treatments has been limited by unreliable supplies, cost, and difficulty in obtaining therapeutic quantities.
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KEYWORD
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Cu-67, Cu-64, Copper, Chelator, Radioisotope, Radiopharmaceutical, Nuclear medicine
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